Computing by Splicing
نویسندگان
چکیده
Computing by splicing is a new powerful tool stemming originally from molecular genetics. This new model of computing, splicing systems, is investigated here. Several variants, resulting from the use of the rules in different ways, are considered. The power of such systems with very weak structure imposed on rules turns out to be very large. Characterizations of recursively enumerable languages are obtained for many variants. In this way our study is analogous to the early studies concerning variations of Turing machines. Other classes of such splicing systems generate only regular or context-free languages (giving, in fact, characterizations of these families). With a few exceptions, we are able to obtain precise characterizations for all resulting families.
منابع مشابه
Sodium Butyrate and Valproic Acid as Splicing Restoring Agents in Erythroid Cells of b-Thalassemic Patients
Background: b-Thalassemia is a common autosomal recessive disorder in human caused by a defect in b-globin chain synthesis. The most common mutations causing b-Thalassemia have been found to be splicing mutations. Most of which activate aberrant cryptic splicing/sites without complete disruption of normal splicing. IVSI-110 mutation, a common splicing mutation, leads to a 90% reduction of norma...
متن کاملRestoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: implications and applications in functional assay development
Objective(s): The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of potentially controlling certain inherited disorders affected by aberrant splicing. Selection of the appropriate target site is essential in the success of an AO therapy. In this study, in search for a splic...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملDNA Computing Based on Splicing: The Existence of Universal Computers.dvi
Splicing systems are generative mechanisms based on the splicing operation introduced by Tom Head as a model of DNA recombination. We prove that the generative power of finite extended splicing systems equals that of Turing machines, provided we consider multisets or provided a control mechanism is added. We also show that there exist universal splicing systems with the properties above, i. e. ...
متن کاملA Nested-Splicing by Overlap Extension PCR Improves Specificity of this Standard Method
Background: Splicing by overlap extension (SOE) PCR is used to create mutation in the coding sequence of an enzyme in order to study the role of specific residues in protein’s structure and function. Objectives: We introduced a nested-SOE-PCR (N –SOE-PCR) in order to increase the specificity and generating mutations in a gene by SOE-PCR. Materials and Methods: Genomic DNA from Bacillus thermo...
متن کاملSimulating Boolean circuits by finite splicing
As a computational model to be simulated in a DNA computing context, Boolean circuits are especially interesting because of their parallelism. Simulations in concrete biochemical computing settings have been given by [OR96] and [AD97]. In this paper, we show how to simulate Boolean circuits by finite splicing systems, an abstract model of enzymatic recombination ([Hea87], [Gat94], [Pǎu96a]). We...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Theor. Comput. Sci.
دوره 168 شماره
صفحات -
تاریخ انتشار 1996